The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
Python applications and libraries for working with PGS data and the PGS Catalog
An open database of polygenic scores and relevant metadata needed to apply and evaluate them correctly.
(superseded by pygscatalog) Utilities for working with PGS Catalog API and scoring files
Privacy-first polygenic risk score analysis. Upload your DNA, get trait scores — all processing happens on your device. Built on DuckDB WASM, Web Components, and the PGS Catalog. No accounts, no servers, no data leaves your browser.
Web-based Polygenic Risk Score calculator for 50+ diseases using PGS Catalog. Supports 23andMe, AncestryDNA, VCF. Ancestry-aware normalization for EUR/AFR/EAS/SAS/AMR. By Luis Sanchez (UC Berkeley) & Shubhankar Tripathy (Stanford).
An AI agent that turns the DNA file you already have (23andMe, AncestryDNA, whole genome) into a polygenic risk score, choosing the model for each person and refusing honestly when the data can't support one. Research tool, not medical advice.
🧬 A suite of Python CLI utilities for bioinformatics: automated PGS to PLINK conversion, genome build liftovers (hg19/hg38), and ISOGG ↔ Y-DNA haplogroup converter
Turn raw 23andMe/AncestryDNA data into a private, local HTML health report — clinical variants (ClinVar, AlphaMissense), pharmacogenomics (PharmGKB), and polygenic risk scores (PGS Catalog), plus an optional AI summary. Runs 100% locally; your genome is never uploaded.
Fast, exact polygenic scores from gVCFs: the whole PGS Catalog per genome in minutes, using reference blocks, no imputation
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