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jacgonisa/README.md

Jacob González Isa

PhD Student in Plant Sciences (Bioinformatics) | University of Cambridge

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Evolution is to me the most fascinating thing in Life.

I love fundamental research - I have been passionate about dissecting the principles of Life and Evolution since I was very young. Academic research allows me to think freely. For that, I chose to research the most paradoxical genomic region: the centromere. This is one of the most important regions in the chromosome and, strikingly, is the region that evolves more rapidly!

I do much wet lab, but I am particularly trained in Bioinformatics. With the power of Computational Biology, I am driven to understand the complexities of Plant Sciences and unlock novel insights in agriculture, sustainability, and ecological preservation.

Last and most importantly, as a first-gen uni student, I am very concerned about the unequal access to the university system between social classes. I actively fight against that problem.

🌱 Plants are my plans for the future!

About me

I'm a PhD student at the University of Cambridge (Department of Plant Sciences & King's College), funded by the "la Caixa" Foundation Postgraduate Fellowship. My research focuses on bioinformatics, phylogenomics, and comparative genomics in plant sciences.

  • Working in the Genetic and Epigenetic Inheritance in Plants group (Prof. Henderson)
  • Funded by "la Caixa" Foundation Postgraduate Fellowship - Selected from 1000+ applicants (€120,000+ funding)
  • MSc in Computational Biology| BSc (Hons) in Biochemistry
  • 📊 Pipeline development, Nextflow, HPC computing (SLURM), long-read analysis, and comparative genomics
  • 🎓 Supervisor for "Mathematical and Computational Biology" course at Cambridge

Tech Stack & Tools

Programming Languages

Python R Bash SQL

Bioinformatics and Data Science

Nextflow ETE Toolkit Apache Spark Machine Learning SLURM

Current research focus

  • Phylogenomics and comparative genomics across plant species
  • Genetic and epigenetic inheritance in plants
  • Bioinformatics pipeline development for genomic analysis
  • Long-read sequencing analysis and genome assembly
  • Metagenomic functional enzyme detection

Selected Publications

Włodzimierz, P., Perez-Roman, E., et al. (including González-Isa, J.) (2025). Cyclical evolution of centromere architecture across 193 eukaryote species. In review

GitHub Stats

GitHub Streak

GitHub activity graph

Let's connect!

I'm always interested in collaborating on exciting projects in computational biology, plant genomics, and bioinformatics. Feel free to reach out!

Email LinkedIn Cambridge Email

"Plants are my plans for the future!"

Profile Views

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  1. MetEOr MetEOr Public

    Pipeline developed during my MSc thesis: "Detection of Metagenomic Enzyme Variants of Biotechnological and Ecological Interest: The Case of Plastic-Degrading Enzymes"

    Python 1

  2. CENprofiler CENprofiler Public

    HTML

  3. DToL_phylogenomics DToL_phylogenomics Public

    Scripts to analyze >300 Darwin Tree of Life (DToL) species, for the paper https://www.researchsquare.com/article/rs-7008504/v1

    Python

  4. entropia-msa entropia-msa Public

    Python

  5. groupsim-py3 groupsim-py3 Public

    Python

  6. sv-satellite-analyzer sv-satellite-analyzer Public

    Python