Issues

• Thyroid tumor POLE signature analysis

  mechanistictier-2
  Bloomed-Health/POLE-Frameshift#8 · Filter by author bloo-berries opened on Apr 15, 2026

• AMA-specific ELISA + extended autoimmune panel

  blood-basedtier-1
  Bloomed-Health/POLE-Frameshift#7 · Filter by author bloo-berries opened on Apr 15, 2026

• MMR IHC, MSI testing, MLH1 methylation analysis

  mechanistictier-1
  Bloomed-Health/POLE-Frameshift#6 · Filter by author bloo-berries opened on Apr 15, 2026

• Immunophenotyping + TCR repertoire sequencing

  blood-basedtherapeutictier-1
  Bloomed-Health/POLE-Frameshift#5 · Filter by author bloo-berries opened on Apr 15, 2026

• CHIP profiling + duplex sequencing / NanoSeq on PBMCs

  blood-basedmechanistictier-1
  Bloomed-Health/POLE-Frameshift#4 · Filter by author bloo-berries opened on Apr 15, 2026

• Allele-specific expression / NMD escape test

  blood-basedmechanistictier-1
  Bloomed-Health/POLE-Frameshift#3 · Filter by author bloo-berries opened on Apr 15, 2026

• Mutational signature decomposition (SBS10a/b/28 vs. alternatives)

  mechanistictier-1
  Bloomed-Health/POLE-Frameshift#2 · Filter by author bloo-berries opened on Apr 15, 2026

• Paired tumor-normal WGS with LOH analysis at POLE locus

  mechanistictier-1
  Bloomed-Health/POLE-Frameshift#1 · Filter by author bloo-berries opened on Apr 15, 2026