diff --git a/rollup.config.js b/rollup.config.js
index 43d743c..3148274 100644
--- a/rollup.config.js
+++ b/rollup.config.js
@@ -46,10 +46,14 @@ function create_configuration({ plugin_name, input, format, optimize }) {
 
     return {
         input,
+        external: ["dompurify"],
         treeshake: "smallest",
         output: {
             file: `dist/${plugin_name}/alpinegear-${plugin_name}${ext_format}${ext_min}.js`,
             format: format,
+            globals: {
+                dompurify: "DOMPurify"
+            },
             plugins: optimize && [terser({
                 output: {
                     comments: false
diff --git a/src/plugins/safehtml/README.md b/src/plugins/safehtml/README.md
index 636fe1d..2d37801 100644
--- a/src/plugins/safehtml/README.md
+++ b/src/plugins/safehtml/README.md
@@ -3,21 +3,26 @@
 `@ramstack/alpinegear-safehtml` provides the `x-safehtml` Alpine.js directive.
 It renders reactive HTML after sanitizing it with DOMPurify.
 
+DOMPurify is a peer dependency and is not bundled with the plugin.
+
 ## Installation
 
 ### Using CDN
 
-Include the plugin before Alpine.js:
+Include DOMPurify before the plugin, and the plugin before Alpine.js:
 
 ```html
+<script src="https://cdn.jsdelivr.net/npm/dompurify@3/dist/purify.min.js" defer></script>
 <script src="https://cdn.jsdelivr.net/npm/@ramstack/alpinegear-safehtml@1/alpinegear-safehtml.min.js" defer></script>
 <script src="https://cdn.jsdelivr.net/npm/alpinejs@3/dist/cdn.min.js" defer></script>
 ```
 
+If DOMPurify is already loaded on the page, reuse it instead of adding another script.
+
 ### Using NPM
 
 ```bash
-npm install --save @ramstack/alpinegear-safehtml
+npm install --save @ramstack/alpinegear-safehtml dompurify@3
 ```
 
 ```js
@@ -46,6 +51,11 @@ or a custom `mapAttributes` shorthand, `x-ignore` keeps it inert.
 
 ## Configuration
 
+The plugin creates a private DOMPurify instance when it is registered with Alpine.
+Calls to `DOMPurify.setConfig()` or `DOMPurify.addHook()` on the application's instance do not affect the plugin,
+and the plugin does not change the application's configuration or hooks.
+The library code is shared; only the instance state is separate.
+
 Global DOMPurify options can be declared in a `meta` element:
 
 ```html
diff --git a/src/plugins/safehtml/index.js b/src/plugins/safehtml/index.js
index 05ee148..9b2e175 100644
--- a/src/plugins/safehtml/index.js
+++ b/src/plugins/safehtml/index.js
@@ -1,4 +1,4 @@
-import DOMPurify from "dompurify";
+import create_dompurify from "dompurify";
 import { parse_options } from "@/utilities/options";
 
 const directive_name = "safehtml";
@@ -6,6 +6,7 @@ const meta_options_selectors = "meta[name='alpinegear-safehtml-options']";
 const data_options_attribute = "data-safehtml-options";
 
 function plugin({ bind, directive, mutateDom: mutate_dom, prefixed }) {
+    const purifier = create_dompurify(window);
     let global_options;
 
     directive(directive_name, (el, { expression }, { effect, evaluateLater: evaluate_later }) => {
@@ -24,7 +25,7 @@ function plugin({ bind, directive, mutateDom: mutate_dom, prefixed }) {
         };
 
         effect(() => evaluate(value => {
-            const html = DOMPurify.sanitize(value, options);
+            const html = purifier.sanitize(value, options);
 
             mutate_dom(() => {
                 el.innerHTML = html;
diff --git a/src/plugins/safehtml/package.json b/src/plugins/safehtml/package.json
index 3f37118..5ee4233 100644
--- a/src/plugins/safehtml/package.json
+++ b/src/plugins/safehtml/package.json
@@ -18,6 +18,9 @@
     "alpinejs-directive",
     "alpinejs-plugin"
   ],
+  "peerDependencies": {
+    "dompurify": "^3.4.15"
+  },
   "exports": {
     ".": {
       "import": {
diff --git a/tests/playwright/assets/page.html b/tests/playwright/assets/page.html
index c7e44f5..b7bbe68 100644
--- a/tests/playwright/assets/page.html
+++ b/tests/playwright/assets/page.html
@@ -16,6 +16,7 @@
   <script src="../../../dist/main/alpinegear-main.js"></script>
   <script src="../../../dist/destroy/alpinegear-destroy.js"></script>
   <script src="../../../dist/hotkey/alpinegear-hotkey.js"></script>
+  <script src="../../../node_modules/dompurify/dist/purify.min.js"></script>
   <script src="../../../dist/safehtml/alpinegear-safehtml.js"></script>
   <script src="../../../dist/markdown/alpinegear-markdown.js"></script>
   <script src="../../../dist/typegrab/alpinegear-typegrab.js"></script>
diff --git a/tests/playwright/x-safehtml.spec.js b/tests/playwright/x-safehtml.spec.js
index fc7461b..04f31e5 100644
--- a/tests/playwright/x-safehtml.spec.js
+++ b/tests/playwright/x-safehtml.spec.js
@@ -54,6 +54,40 @@ test("x-safehtml merges global and local options", async ({ page }) => {
     await expect(content.locator("em")).toHaveText("Local");
 });
 
+test("x-safehtml isolates DOMPurify configuration and hooks", async ({ page }) => {
+    await page.addInitScript(() => {
+        document.addEventListener("alpine:init", () => {
+            DOMPurify.setConfig({ ALLOWED_TAGS: ["strong"], RETURN_DOM: true });
+            DOMPurify.addHook("afterSanitizeAttributes", node => {
+                if (node.nodeName === "STRONG") {
+                    node.setAttribute("data-shared", "yes");
+                }
+            });
+        });
+    });
+
+    await set_html(page, `
+        <div x-data="{ content: '<p title=removed><strong>Shared</strong><em>Local</em></p>' }">
+            <div id="content" x-safehtml="content" data-safehtml-options='{ "FORBID_ATTR": ["title"] }'></div>
+        </div>`);
+
+    const content = page.locator("#content");
+
+    await expect(content.locator("p")).toHaveText("SharedLocal");
+    await expect(content.locator("p")).not.toHaveAttribute("title");
+    await expect(content.locator("strong")).toHaveText("Shared");
+    await expect(content.locator("strong")).not.toHaveAttribute("data-shared");
+    await expect(content.locator("em")).toHaveText("Local");
+
+    expect(await page.evaluate(() => {
+        const result = DOMPurify.sanitize("<p><strong>Shared</strong><em>Local</em></p>");
+        return { nodeType: result.nodeType, html: result.innerHTML };
+    })).toEqual({
+        nodeType: 1,
+        html: '<strong data-shared="yes">Shared</strong>Local'
+    });
+});
+
 test("x-safehtml ignores invalid local options", async ({ page }) => {
     const warnings = [];
     page.on("console", message => message.type() === "warning" && warnings.push(message.text()));